Article

Reference-based annotation of single cell transcriptomes identifies a profibrotic macrophage niche after tissue injury

2018-03-19

Abstract excerpt

Myeloid cells localize to peripheral tissues in a wide range of pathologic contexts. However, appreciation of distinct myeloid subtypes has been limited by the signal averaging inherent to bulk sequencing approaches. Here we applied single-cell RNA sequencing (scRNA-seq) to map cellular heterogeneity in lung fibrosis induced by bleomycin injury in mice. We first developed a computational framework that enables unb...

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Literature Corpus work: 591940a7-0e35-56d8-b8cf-3fd46ad8d954
DOI: 10.1101/284604

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