Article
The Role of Mutated Calreticulin in the Pathogenesis of BCR-ABL1-Negative Myeloproliferative Neoplasms.
International journal of molecular sciences - 12 Sept 2024
Vadeikienė Roberta, Jakštys Baltramiejus, Laukaitienė Danguolė, Šatkauskas Saulius, Juozaitytė Elona, Ugenskienė Rasa
Abstract excerpt
Myeloproliferative neoplasms (MPNs) are characterized by increased proliferation of myeloid lineages in the bone marrow. Calreticulin (CALR) 52 bp deletion and CALR 5 bp insertion have been identified in essential thrombocythemia (ET) and primary myelofibrosis (PMF). There is not much data on the crosstalk between mutated CALR and MPN-related signaling pathways, such as JAK/STAT, PI3K/Akt/mTOR, and Hedgehog....
Topics
- Humans
- Calreticulin
- DNA Damage
- Fusion Proteins, bcr-abl
- Mutation
- Myeloproliferative Disorders
- Oxidative Stress
- Phosphatidylinositol 3-Kinases
- Signal Transduction
- TOR Serine-Threonine Kinases