Somatic mutations in calreticulin can be found in pedigrees with familial predisposition to myeloproliferative neoplasms

Abstract excerpt

Somatic mutations in calreticulin can be found in pedigrees with familial predisposition to myeloproliferative neoplasms JAK2-V617F is the most frequently observed somatic mutation in patients with myeloproliferative neoplasms (MPNs). 1,2Recently, mutations in CALR were described in patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF) that were negative for JAK2-V617F. 3,4All CALR...

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