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Article

Two dynamic N-terminal regions are required for function in ribosomal RNA adenine dimethylase family members.

RNA (New York, N.Y.) - 22 Jan 2025

McGaha Danielle A, Collins Alexandrea, Ajisafe Luqman O, Perdigao Calvin C, Bondrowski Jordan L, Fetsch Karen, Dunkle Jack A

Abstract excerpt

Prominent members of the ribosomal RNA adenine dimethylase (RRAD) family of enzymes facilitate ribosome maturation by dimethylating 2 nt of small subunit rRNA, including the human DIMT1 and bacterial KsgA enzymes. A subgroup of RRAD enzymes, named erythromycin resistance methyltransferases (Erm), dimethylate a specific nucleotide in large subunit rRNA to confer antibiotic resistance. How these enzymes regulate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39516040
DOI: 10.1261/rna.080068.124
PMCID: PMC11789486

Genes

RRAD
DIMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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