Article
Mechanistic insight into the ribosome biogenesis functions of the ancient protein KsgA.
Molecular microbiology - 1 Dec 2008
Connolly Keith, Rife Jason P, Culver Gloria
Abstract excerpt
While the general blueprint of ribosome biogenesis is evolutionarily conserved, most details have diverged considerably. A striking exception to this divergence is the universally conserved KsgA/Dim1p enzyme family, which modifies two adjacent adenosines in the terminal helix of small subunit ribosomal RNA (rRNA). While localization of KsgA on 30S subunits [small ribosomal subunits (SSUs)] and genetic interaction...
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