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Article

Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine.

Scientific reports - 20 Apr 2017

Koh Cha San, Madireddy Rohini, Beane Timothy J, Zamore Phillip D, Korostelev Andrei A

Abstract excerpt

Eubacterial ribosomal large-subunit methyltransferase H (RlmH) methylates 23S ribosomal RNA pseudouridine 1915 (Ψ1915), which lies near the ribosomal decoding center. The smallest member of the SPOUT superfamily of methyltransferases, RlmH lacks the RNA recognition domain found in larger methyltransferases. The catalytic mechanism of RlmH enzyme is unknown. Here, we describe the structures of RlmH bound to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28428565
DOI: 10.1038/s41598-017-01186-5
PMCID: PMC5430550

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