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Article

Ribosomal A site binding pattern differs between Arm methyltransferases from clinical pathogens and a natural producer of aminoglycosides.

International journal of biological macromolecules - 1 Dec 2024

Obranić Sonja, Babić Fedora, Močibob Marko, Maravić-Vlahoviček Gordana

Abstract excerpt

The extensive use of aminoglycosides to treat bacterial infections has led to significant resistance, posing a global health threat. Recent clinical reports highlight high levels of aminoglycoside resistance due to Arm/Kam methyltransferases, which methylate specific nucleotides in 16S rRNA, preventing antibiotic binding to the ribosome. This study compared the ribosomal A site binding patterns of Arm...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39481738
DOI: 10.1016/j.ijbiomac.2024.137015

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