Article

Alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior

2019-12-10

Abstract excerpt

Alcohol use adversely impacts the life of millions of people worldwide. Deficits in synaptic transmission and in microglial function are common findings in human alcohol users and in animal models of alcohol intoxication. Here, we show that alcohol intake over ten consecutive days resulted in substantial loss of excitatory synapse in the prefrontal cortex, a consequence of aberrant synaptic pruning, which led to i...

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Literature Corpus work: e90b873b-d9d0-5f6d-bdfe-9321d9cffdd6
DOI: 10.1101/870279

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