Article

Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome

2024-02-19

Abstract excerpt

<title>Abstract</title> <p>Background Acute radiation syndrome (ARS) manifests after exposure to high doses of radiation in the instances of radiologic accidents or incidents. Facilitating the regeneration of the bone marrow (BM), namely the hematopoietic stem and progenitor cells (HSPCs), is a key in mitigating ARS and multi-organ failure. JNJ-26366821, a PEGylated thrombopoietin mimetic (TPOm) peptide, has bee...

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Literature Corpus work: 4585a6f5-300b-57a6-8d5e-774d40c0f254
DOI: 10.21203/rs.3.rs-3946910/v1

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