From mutation to degradation: predicting nonsense-mediated mRNA decay with NMDap.

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is a critical post-transcriptional surveillance mechanism that degrades transcripts with premature termination codons, safeguarding transcriptome integrity and shaping disease phenotypes. However, accurately predicting NMD activity remains challenging, as existing models often rely on simplistic rule-based heuristics or limited feature sets, constraining their accuracy and...

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