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Genomic stop codon scanning reveals quantitative principles of nonsense-mediated mRNA decay

2025-12-23

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) degrades transcripts containing premature termination codons (PTCs), critically shaping the disease outcomes of protein-truncating variants. While existing NMD rules categorize PTCs as NMD-triggering or NMD-evading, they cannot quantitatively predict the degree of NMD activity for a given endogenous PTC variant. To provide quantitative insight into NMD, we used saturation genome...

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Literature Corpus work
b54e869c-32e9-5a56-8508-99fca7f3c359
DOI
10.64898/2025.12.20.695734
Open publication

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Genomic stop codon scanning reveals quantitative principles of nonsense-mediated mRNA decayDOI 10.64898/2025.12.20.695734
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