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PD-L2 of tumor-derived exosomes mediates the immune escape of cancer cells via the impaired T cell function

7 Nov 2024

Abstract excerpt

Abstract The function of PD-1/PD-L1 axis have been intensively studied for immune escape of various cancers. However, the underlying function of PD-L2 remains poorly understood. Here, we demonstrate that PD-L2 is majorly expressed in exosomes with surface localization by clear cell renal cell carcinoma (ccRCC) cells. Tumor cell-derived exosome PD-L2 (TDE-PD-L2) exhibits high expression compared with TDE-PD-L1 in...

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PMID: 39511147
DOI: 10.1038/s41419-024-07191-7

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