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Programmed cell death-ligand 2: A neglected but important target in the immune response to cancer?

1 Jul 2020

Abstract excerpt

Programmed cell death-ligand 2 (PD-L2) is one of the two ligands of the programmed cell death-1 (PD-1) receptor, an inhibitory protein mainly expressed on activated immune cells that is targeted in the clinic, with successful and remarkable results. The PD-1/PD-Ls axis was shown to be one of the most relevant immunosuppressive pathways in the immune microenvironment, and blocking this interaction gave rise to an...

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PMID: 32622310
DOI: 10.1016/j.tranon.2020.100811

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