Article

Esophageal cancer-derived exosomes imbalance Tfh/Tfr cell ratio in the tumor immune microenvironment via EXO-PDL1 to promote immunosuppression

2023-04-19

Abstract excerpt

<h4>Background: </h4> Esophageal cancer (EC) is a deadly malignancy. Exosomal programmed death ligand 1 (EXO-PDL1) induces immune escape to promote tumor progression. Furthermore, the imbalance between follicular helper T cells (Tfh) and follicular regulatory T cells (Tfr) numbers is related to the progression of many malignant tumors. However, the role of the EC-derived EXO-PDL1 in Tfh/Tfr ratio is unknown. <h4>...

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Literature Corpus work: 4cef3da6-9bf5-50b7-9963-42d300edae87
DOI: 10.21203/rs.3.rs-2824635/v1

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