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Article

Inhibiting YAP1 reduced abdominal aortic aneurysm formation by suppressing adventitial fibroblast phenotype transformation and migration.

Journal of cellular and molecular medicine - 1 Nov 2024

Xie Cuiping, Hu Yanting, Yin Zhehui

Abstract excerpt

The adventitial fibroblast (AF) is the most abundant cell in the vascular adventitia, a few studies had confirmed that AF contributed to abdominal aortic aneurysm (AAA) development; YAP1 involved in several vascular diseases by promoting AF transformed to myofibroblast, the role of YAP1 in AAA is not clear yet. This study aims to determine whether YAP1 play a role in AAA process by regulating AF function. We...

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Share to Adaptor Proteins, Signal Transducing
Share to Aortic Aneurysm, Abdominal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Disease Models, Animal

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Source

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Identifiers

PMID: 39495769
DOI: 10.1111/jcmm.70159
PMCID: PMC11534076

Genes

YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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