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DNA damage response defects in hematologic malignancies: mechanistic insights and therapeutic strategies

8 Mar 2024

Abstract excerpt

ABSTRACT: The DNA damage response (DDR) encompasses the detection and repair of DNA lesions and is fundamental to the maintenance of genome integrity. Germ line DDR alterations underlie hereditary chromosome instability syndromes by promoting the acquisition of pathogenic structural variants in hematopoietic cells, resulting in increased predisposition to hematologic malignancies. Also frequent in hematologic...

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PMID: 38457665
DOI: 10.1182/blood.2023019963

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