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Article

Relationship between SLCO1B1 polymorphisms and methotrexate intolerance in Mexican children with juvenile idiopathic arthritis.

Clinical rheumatology - 1 Dec 2024

Garcia-Silva Jimena, Silva-Ramirez Beatriz, Villarreal-Treviño Ana V, Mata-Tijerina Viviana, Rubio-Perez Nadina E, Garcia-Rodriguez Fernando

Abstract excerpt

INTRODUCTION: The most frequent adverse events (AEs) of methotrexate (MTX) are gastrointestinal symptoms and hepatotoxicity, which can affect its adherence, leading to reduced effectiveness. The SLCO1B1 gene codes for a liver protein (OATP1B1) responsible for drug transportation. Genetic variations within the SLCO1B1 gene locus impact drug transport, leading to altered pharmacokinetic profiles, delayed MTX...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39489878
DOI: 10.1007/s10067-024-07221-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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