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Article

SLCO1B1 variants as predictors of methotrexate-related toxicity in children with juvenile idiopathic arthritis.

Scandinavian journal of rheumatology - 1 May 2021

Roszkiewicz J, Michałek D, Ryk A, Swacha Z, Szmyd B, Smolewska E

Abstract excerpt

Objectives: Methotrexate (MTX) administered at the dose 10-15 mg/m2 is currently recommended as the first line therapy in most juvenile idiopathic arthritis (JIA) subtypes. Gastrointestinal side effects and hepatotoxicity are the most prevalent manifestations of MTX intolerance, frequently leading to discontinuation of otherwise effective treatment. Genetic variability within solute carrier organic anion...

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PMID: 33025831
DOI: 10.1080/03009742.2020.1818821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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