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Article

Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition.

Genome research - 1 Jan 2012

Ramsey Laura B, Bruun Gitte H, Yang Wenjian, Treviño Lisa R, Vattathil Selina, Scheet Paul, Cheng Cheng, Rosner Gary L, Giacomini Kathleen M, Fan Yiping, Sparreboom Alex, Mikkelsen Torben S, Corydon Thomas J, Pui Ching-Hon, Evans William E, Relling Mary V

Abstract excerpt

Methotrexate is used to treat autoimmune diseases and malignancies, including acute lymphoblastic leukemia (ALL). Inter-individual variation in clearance of methotrexate results in heterogeneous systemic exposure, clinical efficacy, and toxicity. In a genome-wide association study of children with ALL, we identified SLCO1B1 as harboring multiple common polymorphisms associated with methotrexate clearance. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22147369
DOI: 10.1101/gr.129668.111
PMCID: PMC3246196

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