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Article

SLC19A1, SLC46A1 and SLCO1B1 polymorphisms as predictors of methotrexate-related toxicity in Portuguese rheumatoid arthritis patients.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Nov 2014

Lima Aurea, Bernardes Miguel, Azevedo Rita, Monteiro Joaquim, Sousa Hugo, Medeiros Rui, Seabra Vítor

Abstract excerpt

Methotrexate (MTX) is used for rheumatoid arthritis (RA) treatment showing a wide toxicity profile. This study aimed to evaluate the influence of single nucleotide polymorphisms (SNPs) in genes encoding for MTX transporters with the occurrence of MTX-related toxicity (overall and gastrointestinal). A total of 233 Portuguese RA patients were genotyped for 23 SNPs. Haplotype analyses were performed and a...

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Identifiers

PMID: 25124723
DOI: 10.1093/toxsci/kfu162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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