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Article

Relationship Between Polymorphisms in Methotrexate Pathway Genes and Outcome of Methotrexate Treatment in a Cohort of 119 Patients with Juvenile Idiopathic Arthritis.

The Journal of rheumatology - 1 Aug 2017

Zajc Avramovič Mojca, Dolžan Vita, Toplak Nataša, Accetto Meta, Lusa Lara, Avčin Tadej

Abstract excerpt

OBJECTIVE: To identify clinical and pharmacogenetic determinants of efficacy and toxicity of methotrexate (MTX) in juvenile idiopathic arthritis (JIA) over time. METHODS: A cohort of 119 consecutive patients with JIA treated with MTX was reviewed. The Juvenile Arthritis Disease Activity Score including 71 joints was used to measure disease activity. Nonresponders were patients who did not reach a minimum of 30%...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

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Share to Methylenetetrahydrofolate Dehydrogenase (NADP)

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Source

Identifiers

PMID: 28572465
DOI: 10.3899/jrheum.160950

Genes

ABCC2
MTHFR
MTRR
ABCG2
AMPD1
MTHFD1
MTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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