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Article

Prediction of methotrexate intolerance in juvenile idiopathic arthritis: a prospective, observational cohort study.

Pediatric rheumatology online journal - 1 Jan 2015

van Dijkhuizen Evert Hendrik Pieter, Bulatović Ćalasan Maja, Pluijm Saskia M F, de Rotte Maurits C F J, Vastert Sebastiaan J, Kamphuis Sylvia, de Jonge Robert, Wulffraat Nico M

Abstract excerpt

BACKGROUND: Methotrexate (MTX) is an effective and safe drug in the treatment of juvenile idiopathic arthritis (JIA). Despite its safety, MTX-related gastrointestinal adverse effects before and after MTX administration, termed MTX intolerance, occur frequently, leading to non-compliance and potentially premature MTX termination. The aim of this study was to construct a risk model to predict MTX intolerance....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25745368
DOI: 10.1186/s12969-015-0002-3
PMCID: PMC4349799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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