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<i>ABCB1</i>and<i>ABCC3</i>Gene Polymorphisms Are Associated with First-year Response to Methotrexate in Juvenile Idiopathic Arthritis

1 Aug 2012

Abstract excerpt

OBJECTIVE: Although methotrexate (MTX) is the most widely prescribed drug in juvenile idiopathic arthritis (JIA), 30% of patients fail to respond to it. To individualize treatment strategies, the genetic determinants of response to MTX should be identified. METHODS: A cohort of 287 patients with JIA treated with MTX was studied longitudinally over the first year of treatment. MTX response was defined as the...

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PMID: 22859359
DOI: 10.3899/jrheum.111593

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