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Article

Single nucleotide polymorphisms associated with methotrexate-induced nausea in juvenile idiopathic arthritis.

Pediatric rheumatology online journal - 1 Apr 2021

Kyvsgaard Nini, Mikkelsen Torben Stamm, Als Thomas D, Christensen Anne Estmann, Corydon Thomas J, Herlin Troels

Abstract excerpt

BACKGROUND: Context: Methotrexate (MTX) is a cornerstone in the treatment of juvenile idiopathic arthritis (JIA). MTX treatment is commonly associated with nausea. Large inter-individual variation exists in the level of MTX-induced nausea, possibly due to genetic factors. PURPOSE: To investigate whether MTX-induced nausea was associated with single nucleotide polymorphisms (SNPs) in genes encoding MTX-transporter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33794950
DOI: 10.1186/s12969-021-00539-9
PMCID: PMC8017639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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