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Article

Association of SLCO 1B1 *14 Allele with Poor Response to Methotrexate in Juvenile Idiopathic Arthritis Patients

1 Mar 2019

Abstract excerpt

Objective Variants in the SLCO 1B1 gene, encoding a hepatic methotrexate ( MTX ) transporter, affect clearance of high‐dose MTX . We tested whether in the *14 and *15 alleles of SLCO 1B1 influenced the response to low‐dose MTX in juvenile idiopathic arthritis ( JIA ) patients. Methods The study included 310 JIA patients genotyped for three single nucleotide polymorphisms ( SNP s) in SLCO 1B1 (rs4149056,...

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PMID: 31777781
DOI: 10.1002/acr2.1008

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