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Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury

6 Dec 2022

Abstract excerpt

Severe lung damage resulting from COVID-19 involves complex interactions between diverse populations of immune and stromal cells. In this study, we used a spatial transcriptomics approach to delineate the cells, pathways, and genes present across the spectrum of histopathological damage in COVID-19-affected lung tissue. We applied correlation network-based approaches to deconvolve gene expression data from 46...

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PMID: 36472908
DOI: 10.1172/jci.insight.157837

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