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Benchmarking and building DNA binding affinity models using allele-specific and allele-agnostic transcription factor binding data.

Genome biology - 31 Oct 2024

Li Xiaoting, Melo Lucas A N, Bussemaker Harmen J

Abstract excerpt

BACKGROUND: Transcription factors (TFs) bind to DNA in a highly sequence-specific manner. This specificity manifests itself in vivo as differences in TF occupancy between the two alleles at heterozygous loci. Genome-scale assays such as ChIP-seq currently are limited in their power to detect allele-specific binding (ASB) both in terms of read coverage and representation of individual variants in the cell lines...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39482734
DOI: 10.1186/s13059-024-03424-2
PMCID: PMC11529166

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TF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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