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Article

BaalChIP: Bayesian analysis of allele-specific transcription factor binding in cancer genomes.

Genome biology - 24 Feb 2017

de Santiago Ines, Liu Wei, Yuan Ke, O'Reilly Martin, Chilamakuri Chandra Sekhar Reddy, Ponder Bruce A J, Meyer Kerstin B, Markowetz Florian

Abstract excerpt

Allele-specific measurements of transcription factor binding from ChIP-seq data are key to dissecting the allelic effects of non-coding variants and their contribution to phenotypic diversity. However, most methods of detecting an allelic imbalance assume diploid genomes. This assumption severely limits their applicability to cancer samples with frequent DNA copy-number changes. Here we present a Bayesian...

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Identifiers

PMID: 28235418
DOI: 10.1186/s13059-017-1165-7
PMCID: PMC5326502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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