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Article

Testosterone acts through the membrane protein GPRC6A to cause cardiac edema in zebrafish embryos.

Development (Cambridge, England) - 1 Dec 2024

Zadmajid Vahid, Shahriar Shayan, Gorelick Daniel A

Abstract excerpt

Androgens are classically thought to act through intracellular androgen receptors (AR/NR3C4), but they can also trigger non-genomic effects via membrane proteins. Although several membrane androgen receptors have been characterized in vitro, their functions in vivo remain unclear. Using a chemical-genetic screen in zebrafish, we found that GPRC6A, a G-protein-coupled receptor, mediates non-genomic androgen...

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Share to Androgens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Androgen

Share to Receptors, G-Protein-Coupled

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Source

Open in PubMed Open full text

Identifiers

PMID: 39479956
DOI: 10.1242/dev.204390
PMCID: PMC11634029

Genes

GPRC6A
AR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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