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Article

Adgrg6/Gpr126 is required for compact wall integrity and establishing trabecular identity during cardiac trabeculation.

Nature communications - 7 Feb 2026

Srivastava Swati, Gunawan Felix, Vergarajauregui Silvia, Gentile Alessandra, Angeloni Miriam, Petersen Sarah C, Günther Stefan, Ferrazzi Fulvia, Stainier Didier Y R, Engel Felix B

Abstract excerpt

How adhesion G protein-coupled receptors (aGPCRs) control development remains unclear. aGPCR Adgrg6/Gpr126 has been associated with heart trabeculation. Defects in this process cause cardiomyopathies and cardiac dysfunction. How cardiomyocytes attain trabecular identity is poorly understood. Here, we show that different domains of Gpr126 distinctly regulate compact wall integrity and trabecular identity. Maternal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41654504
DOI: 10.1038/s41467-026-69292-5
PMCID: PMC12886893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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