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Article

The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5.

Scientific reports - 13 Sept 2016

Lessel Davor, Muhammad Tariq, Casar Tena Teresa, Moepps Barbara, Burkhalter Martin D, Hitz Marc-Phillip, Toka Okan, Rentzsch Axel, Schubert Stephan, Schalinski Adelheid, Bauer Ulrike M M, Kubisch Christian, Ware Stephanie M, Philipp Melanie

Abstract excerpt

G protein-coupled receptor kinase 5 (GRK5) is a regulator of cardiac performance and a potential therapeutic target in heart failure in the adult. Additionally, we have previously classified GRK5 as a determinant of left-right asymmetry and proper heart development using zebrafish. We thus aimed to identify GRK5 variants of functional significance by analysing 187 individuals with laterality defects (heterotaxy)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27618959
DOI: 10.1038/srep33231
PMCID: PMC5020398

Genes

GRK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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