Article
Tumour evolution and microenvironment interactions in 2D and 3D space.
Nature - 1 Oct 2024
Mo Chia-Kuei, Liu Jingxian, Chen Siqi, Storrs Erik, Targino da Costa Andre Luiz N, Houston Andrew, Wendl Michael C, Jayasinghe Reyka G, Iglesia Michael D, Ma Cong, Herndon John M, Southard-Smith Austin N, Liu Xinhao, Mudd Jacqueline, Karpova Alla, Shinkle Andrew, Goedegebuure S Peter, Abdelzaher Abdurrahman Taha Mousa Ali, Bo Peng, Fulghum Lauren, Livingston Samantha, Balaban Metin, Hill Angela, Ippolito Joseph E, Thorsson Vesteinn, Held Jason M, Hagemann Ian S, Kim Eric H, Bayguinov Peter O, Kim Albert H, Mullen Mary M, Shoghi Kooresh I, Ju Tao, Reimers Melissa A, Weimholt Cody, Kang Liang-I, Puram Sidharth V, Veis Deborah J, Pachynski Russell, Fuh Katherine C, Chheda Milan G, Gillanders William E, Fields Ryan C, Raphael Benjamin J, Chen Feng, Ding Li
Abstract excerpt
To study the spatial interactions among cancer and non-cancer cells1, we here examined a cohort of 131 tumour sections from 78 cases across 6 cancer types by Visium spatial transcriptomics (ST). This was combined with 48 matched single-nucleus RNA sequencing samples and 22 matched co-detection by indexing (CODEX) samples. To describe tumour structures and habitats, we defined 'tumour microregions' as spatially...
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