Article

A machine learning classifier trained on cancer transcriptomes detects NF1 inactivation signal in glioblastoma

2016-09-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background: </h4> We have identified molecules that exhibit synthetic lethality in cells with loss of the neurofibromin 1 ( NF1 ) tumor suppressor gene. However, recognizing tumors that have inactivation of the NF1 tumor suppressor function is challenging because the loss may occur via mechanisms that do not involve mutation of the genomic locus. Degradation of the NF1 protein, independent...

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Literature Corpus work: 864002e2-c2e8-5bfa-be82-51f5eab873d6
DOI: 10.1101/075382

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