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Article

Combining Metabolomics and Experimental Evolution Reveals Key Mechanisms Underlying Longevity Differences in Laboratory Evolved Drosophila melanogaster Populations.

International journal of molecular sciences - 19 Jan 2022

Phillips Mark A, Arnold Kenneth R, Vue Zer, Beasley Heather K, Garza-Lopez Edgar, Marshall Andrea G, Morton Derrick J, McReynolds Melanie R, Barter Thomas T, Hinton Antentor

Abstract excerpt

Experimental evolution with Drosophila melanogaster has been used extensively for decades to study aging and longevity. In recent years, the addition of DNA and RNA sequencing to this framework has allowed researchers to leverage the statistical power inherent to experimental evolution to study the genetic basis of longevity itself. Here, we incorporated metabolomic data into to this framework to generate even...

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Identifiers

PMID: 35162994
DOI: 10.3390/ijms23031067
PMCID: PMC8835531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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