Article

Late- life shift in caloric intake affects fly longevity and metabolism

2023-05-14

Abstract excerpt

Caloric restriction (CR) delays the onset of age-related changes and extends lifespan in most species, but how late in life organisms benefit from switching to a low-calorie (L) diet is unexplored. We transferred wild type male flies from a high- (H) to a L-calorie diet (HL) or vice versa (LH) at different times. Late-life HL shift immediately and profoundly reduces fly mortality rate to briefly lower rate than in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: acf7eb9b-4b72-5936-9575-d2ec9adbcd76
DOI: 10.1101/2023.05.11.540262

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Late- life shift in caloric intake affects fly longevity and metabolismDOI 10.1101/2023.05.11.540262Read

The hidden costs of dietary restriction: Implications for its evolutionary and mechanistic origins.Semantic proximity Read

Dietary regulation in health and diseaseSemantic proximity Read

The hidden costs of dietary restriction: implications for its evolutionary and mechanistic originsSemantic proximity Read

Protein Restriction Effects on Healthspan and Lifespan in Drosophila melanogaster Are Additive With a Longevity-Promoting DietSemantic proximity Read

Essential Physiological Differences Characterize Short- and Long-Lived Strains of Drosophila melanogaster.Semantic proximity Read

Diet and aging.Semantic proximity Read

Systematic transcriptomics analysis of calorie restriction and rapamycin unveils their synergistic interaction in prolonging cellular lifespanSemantic proximity Read

Systems biology and machine learning approaches identify metabolites that influence dietary lifespan and healthspan responses across flies and humansSemantic proximity Read

Genome-wide analysis reveals distinct genetic mechanisms of diet-dependent lifespan and healthspan in <i>D. melanogaster</i>Semantic proximity Read

Regulators of health and lifespan extension in genetically diverse mice on dietary restrictionSemantic proximity Read

Metabolic regulation of lifespan from a C. elegans perspectiveSemantic proximity Read

Protein restriction, epigenetic diet, intermittent fasting as new approaches for preventing age-associated diseasesSemantic proximity Read