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Validating Disease Associations of Drug-Metabolizing Enzymes through Genome-Wide Association Study Data Analysis.

Genes - 15 Oct 2024

Leskiw Evan, Whaley Adeline, Hopwood Peter, Houston Tailyn, Murib Nehal, Al-Falih Donna, Fujiwara Ryoichi

Abstract excerpt

BACKGROUND AND OBJECTIVES: Phase I and phase II drug-metabolizing enzymes are crucial for the metabolism and elimination of various endogenous and exogenous compounds, such as small-molecule hormones, drugs, and xenobiotic carcinogens. While in vitro and animal studies have suggested a link between genetic mutations in these enzymes and an increased risk of cancer, human in vivo studies have provided limited...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39457450
DOI: 10.3390/genes15101326
PMCID: PMC11507559

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