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Article

Whole exome sequencing detects variants of genes that mediate response to anticancer drugs.

The Journal of toxicological sciences - 1 Jan 2017

Ohnami Sumiko, Nagashima Takeshi, Urakami Kenichi, Shimoda Yuji, Kamada Fukumi, Saito Junko, Naruoka Akane, Serizawa Masakuni, Masuda Yoko, Ohnami Shumpei, Kusuhara Masatoshi, Yamaguchi Ken

Abstract excerpt

Certain interindividual differences affecting the efficacy of drug treatment and adverse drug reactions are caused by genetic variants, and their phenotypic effects differ among ethnic groups. In this study, we used whole exome sequencing (WES) systematically to identify germline mutations that influence the activities of drug-metabolizing enzymes, as well as that of a transporter. We analyzed DNA isolated from...

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Share to Antineoplastic Agents
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytidine Deaminase

Share to Cytochrome P-450 Enzyme System

Share to Gene Expression Regulation, Neoplastic

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Source

Identifiers

PMID: 28321040
DOI: 10.2131/jts.42.137

Genes

NAT2
ABCB1
CDA
COMT
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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