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Article

Polymorphisms in UDP glucuronosyltransferase genes: functional consequences and clinical relevance.

Clinical chemistry and laboratory medicine - 1 Sept 2000

Mackenzie P I, Miners J O, McKinnon R A

Abstract excerpt

As glucuronidation is a major process for the metabolism and removal of lipophilic chemicals, polymorphic variations in genes encoding the enzymes involved in this process, the UDP glucuronosyltransferases (UGT), may have a significant impact on our capacity to detoxify and eliminate drugs and toxins. Although 24 human UGT genes have been identified to date, only polymorphisms in five UGTs, viz. UGT1A1, UGT1A6,...

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Identifiers

PMID: 11097345
DOI: 10.1515/CCLM.2000.129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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