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Article

Genetic association of lipid and lipid-lowering drug target genes with atopic dermatitis: a drug target Mendelian randomization study.

Scientific reports - 5 Aug 2024

Niu Qinwang, Zhang Tongtong, Mao Rui, Zhao Nana, Deng Sui

Abstract excerpt

Observational studies suggest dyslipidemia as an atopic dermatitis (AD) risk factor and posit that lipid-lowering drugs may influence AD risk, but the causal link remains elusive. Mendelian randomization was applied to elucidate the causal role of serum lipids in AD and assess the therapeutic potential of lipid-lowering drug targets. Genetic variants related to serum lipid traits and lipid-lowering drug targets...

Topics

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Dermatitis, Atopic
Dyslipidemias
Genome-Wide Association Study
Hypolipidemic Agents
Lipids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

Proprotein Convertase 9

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Identifiers

PMID: 39103489
DOI: 10.1038/s41598-024-69180-2
PMCID: PMC11300444

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