An interaction map of circulating metabolites, immune gene networks, and their genetic regulation.

doi:10.1186/s13059-017-1279-y

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Article

An interaction map of circulating metabolites, immune gene networks, and their genetic regulation.

Genome biology - 1 Aug 2017

Nath Artika P, Ritchie Scott C, Byars Sean G, Fearnley Liam G, Havulinna Aki S, Joensuu Anni, Kangas Antti J, Soininen Pasi, Wennerström Annika, Milani Lili, Metspalu Andres, Männistö Satu, Würtz Peter, Kettunen Johannes, Raitoharju Emma, Kähönen Mika, Juonala Markus, Palotie Aarno, Ala-Korpela Mika, Ripatti Samuli, Lehtimäki Terho, Abraham Gad, Raitakari Olli, Salomaa Veikko, Perola Markus, Inouye Michael

Abstract excerpt

BACKGROUND: Immunometabolism plays a central role in many cardiometabolic diseases. However, a robust map of immune-related gene networks in circulating human cells, their interactions with metabolites, and their genetic control is still lacking. Here, we integrate blood transcriptomic, metabolomic, and genomic profiles from two population-based cohorts (total N = 2168), including a subset of individuals with...

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PMID: 28764798
DOI: 10.1186/s13059-017-1279-y
PMCID: PMC5540552

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