Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity.

doi:10.1016/j.intimp.2021.107825

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Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity.

International immunopharmacology - 1 Sept 2021

Cuesta-Llavona Elías, Gómez Juan, Albaiceta Guillermo M, Amado-Rodríguez Laura, García-Clemente Marta, Gutiérrez-Rodríguez José, López-Alonso Inés, Hermida Tamara, Enríquez Ana I, Hernández-González Cristina, Gil-Peña Helena, Domínguez-Garrido Elena, Pérez-Oliveira Sergio, Alvarez Victoria, López-Larrea Carlos, Suarez-Alvarez Beatriz, Tranche Salvador, Jimeno-Demuth Francisco J, Coto Eliecer

Abstract excerpt

The chemokine receptor CCR5 has been implicated in COVID-19. CCR5 and its ligands are overexpressed in patients. The pharmacological targeting of CCR5 would improve the COVID-19 severity. We sought to investigate the role of the CCR5-Δ32 variant (rs333) in COVID-19. The CCR5-Δ32 was genotyped in 801 patients (353 in the intensive care unit, ICU) and 660 healthy controls, and the deletion was significantly less...

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Identifiers

PMID: 34116286
DOI: 10.1016/j.intimp.2021.107825
PMCID: PMC8169316

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