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Clonal hematopoiesis and myeloid skewing in older population‐based individuals

21 Oct 2024

Abstract excerpt

Hematopoietic stem cells (HSCs) continuously produce blood cells while maintaining their self-renewal, proliferation, and differentiation potential. Normal blood cell production is balanced between myeloid and lymphoid progeny. With aging, the number of HSCs increases but their differentiation potential declines.1 One of the hallmarks of aged HSCs is a myeloid differentiation bias, with less capability of...

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PMID: 39429216
DOI: 10.1002/ajh.27495

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