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Clonal Hematopoiesis Defined by Somatic Mutations Infrequently Co-occurs With Mosaic Loss of the Y Chromosome in a Population-based Cohort

13 Sept 2023

Abstract excerpt

With aging, acquired genetic alterations accumulate in hematopoietic stem or progenitor cells. Positive selection may provide a growth advantage for clones carrying driver mutations, and subsequent clonal expansion is called clonal hematopoiesis.1 Mosaic loss of chromosome Y (mLOY) is the most commonly acquired cytogenetic alteration in aging male individuals from the general population.2,3 mLOY associates with...

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PMID: 37720253
DOI: 10.1097/hs9.0000000000000956

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