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Article

Acute Myeloid Leukemia Subtype-Specific Prognostic Value of NGS in the Setting of Intensive Chemotherapy.

American journal of hematology - 1 Oct 2026

Bolarinwa Abiola, Al-Kali Aref, Alkhateeb Hassan B, Mangaonkar Abhishek A, Saliba Antoine N, Torghabeh Mehrdad Hefazi, Matin Aasiya, Elliott Michelle A, Litzow Mark R, Hogan William J, Shah Mithun V, Patnaik Mrinal M, Pardanani Animesh, Foran James M, Badar Talha, Murthy Hermant S, Punwani Nathan, Palmer Jeanne M, Sproat Lisa Z, Chen Dong, Reichard Kaaren K, He Rong, Viswanatha David S, Zepeda-Mendoza Cinthya J, Gangat Naseema, Begna Kebede H, Tefferi Ayalew

Abstract excerpt

We examined the prognostic value of routine NGS data in newly diagnosed acute myeloid leukemia (AML) treated with intensive (7 + 3 backbone) induction, specified by AML subtype. A contemporary (2015-2025) series of 545 Mayo Clinic patients (median age 56 years, females 44%) was considered. Median follow-up was 49 months with 341 (63%) allogeneic hematopoietic stem cell transplantations (AHSCT) recorded. AML...

Read the complete abstract on PubMed

Topics

Humans
Female
Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Nucleophosmin

Prognosis

Middle Aged

Male

Hematopoietic Stem Cell Transplantation

Mutation

High-Throughput Nucleotide Sequencing

Adult

Antineoplastic Combined Chemotherapy Protocols

Source

Open in PubMed Open full text

Identifiers

PMID: 42470254
DOI: 10.1002/ajh.70443
PMCID: PMC13540303

Genes

FLT3
KRAS
NPM1
TET2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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