Article
Liquidity Is a Critical Determinant for Selective Autophagy of Protein Condensates.
Molecular cell - 19 Mar 2020
Yamasaki Akinori, Alam Jahangir Md, Noshiro Daisuke, Hirata Eri, Fujioka Yuko, Suzuki Kuninori, Ohsumi Yoshinori, Noda Nobuo N
Abstract excerpt
Clearance of biomolecular condensates by selective autophagy is thought to play a crucial role in cellular homeostasis. However, the mechanism underlying selective autophagy of condensates and whether liquidity determines a condensate's susceptibility to degradation by autophagy remain unknown. Here, we show that the selective autophagic cargo aminopeptidase I (Ape1) undergoes phase separation to form semi-liquid...
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