Article
Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function.
Communications biology - 17 Oct 2024
Matsunaga Yohei, Qadota Hiroshi, Ghazal Nasab, Lesanpezeshki Leila, Dorendorf Till, Moody Jasmine C, Ahier Arnaud, Matheny Courtney J, Vanapalli Siva A, Zuryn Steven, Mayans Olga, Kwong Jennifer Q, Benian Guy M
Abstract excerpt
UNC-89 is a giant sarcomeric M-line protein required for sarcomere organization and optimal muscle function. UNC-89 contains two protein kinase domains, PK1 and PK2, separated by an elastic region. Here we show that PK2 is a canonical kinase expected to be catalytically active. C. elegans expressing UNC-89 with a lysine to alanine (KtoA) mutation to inactivate PK2 have normally organized sarcomeres and SR, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.