Article
InsP3R signaling and actomyosin-dependent mitochondrial dynamics play essential roles in mitochondrial stress-induced longevity.
Nature communications - 13 Aug 2026
Feng Gaomin, Ruark Elizabeth M, Mulligan Alexandra G, Donahue Eric K F, Hoang Anthony L, Jacquet-Cribe Brianne, Peng Li, Burkewitz Kristopher
Abstract excerpt
Certain forms of mitochondrial impairment confer longevity, while disease-associated mitochondrial dysfunction triggers pathogenesis. The adaptive pathways that distinguish benefit from pathology remain unclear. Here we reveal that longevity induced by mitochondrial Complex I/nuo-6 mutation in C. elegans is dependent on the endoplasmic reticulum (ER) Ca2+ channel, InsP3R. To explain this connection, we test...
Read the complete abstract on PubMedTopics
- Animals
- Caenorhabditis elegans
- Mitochondrial Dynamics
- Longevity
- Mitochondria
- Caenorhabditis elegans Proteins