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Article

Tissue-specific isoforms of the single C. elegans Ryanodine receptor gene unc-68 control specific functions.

PLoS genetics - 1 Oct 2020

Marques Filipe, Thapliyal Saurabh, Javer Avelino, Shrestha Priyanka, Brown André E X, Glauser Dominique A

Abstract excerpt

Ryanodine receptors (RyR) are essential regulators of cellular calcium homeostasis and signaling. Vertebrate genomes contain multiple RyR gene isoforms, expressed in different tissues and executing different functions. In contrast, invertebrate genomes contain a single RyR-encoding gene and it has long been proposed that different transcripts generated by alternative splicing may diversify their functions. Here,...

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PMID: 33104696
DOI: 10.1371/journal.pgen.1009102
PMCID: PMC7644089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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