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Article

Stochastic Boolean model of normal and aberrant cell cycles in budding yeast.

NPJ systems biology and applications - 18 Oct 2024

Taoma Kittisak, Tyson John J, Laomettachit Teeraphan, Kraikivski Pavel

Abstract excerpt

The cell cycle of budding yeast is governed by an intricate protein regulatory network whose dysregulation can lead to lethal mistakes or aberrant cell division cycles. In this work, we model this network in a Boolean framework for stochastic simulations. Our model is sufficiently detailed to account for the phenotypes of 40 mutant yeast strains (83% of the experimentally characterized strains that we simulated)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39420008
DOI: 10.1038/s41540-024-00452-3
PMCID: PMC11487276

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