Article
A stochastic model correctly predicts changes in budding yeast cell cycle dynamics upon periodic expression of CLN2.
PloS one - 1 Jan 2014
Oguz Cihan, Palmisano Alida, Laomettachit Teeraphan, Watson Layne T, Baumann William T, Tyson John J
Abstract excerpt
In this study, we focus on a recent stochastic budding yeast cell cycle model. First, we estimate the model parameters using extensive data sets: phenotypes of 110 genetic strains, single cell statistics of wild type and cln3 strains. Optimization of stochastic model parameters is achieved by an automated algorithm we recently used for a deterministic cell cycle model. Next, in order to test the predictive...
Topics
- Cell Cycle
- Cell Size
- Cyclins
- Gene Expression Regulation, Fungal
- Models, Biological
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Stochastic Processes